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PulseRider支架治疗分叉部宽颈动脉瘤ANSWER试验结果 ResultsoftheANSWERTrialUsingthePulseRiderfortheTreatmentofBroad-Necked,BifurcationAneurysms 神经血管内支架辅助宽颈动脉瘤介入栓塞和载瘤动脉重建（AdjunctiveNeurovascularSupportofWide-neckaneurysmEmbolizationandReconstruction,ANSWER）试验是一项前瞻性、非随机的单组临床试验，对PulseRider支架（PulsarVascular,LosGatos,California）治疗分叉部宽颈动脉瘤的安全性及预期获益进行了研究。 ThesafetyandprobablebenefitofthePulseRider(PulsarVascular,LosGatos,California)forthetreatmentofbroad-necked,bifurcationaneurysmswasstudiedinthecontextoftheprospective,nonrandomized,singlearmclinicaltrial—theAdjunctiveNeurovascularSupportofWide-neckaneurysmEmbolizationandReconstruction(ANSWER)Trial. 目的：介绍ANSWER临床试验中PulseRider支架在美国的应用结果。 OBJECTIVE:TopresenttheresultsoftheUnitedStatescasesemployingthePulseRiderdeviceaspartoftheANSWERclinicaltrial. 方法：对完成ANSWER试验网站注册、使用PulseRider支架治疗的动脉瘤病例进行前瞻性研究，并总结研究结果。研究对象为发生在颈内动脉末端或基底动脉尖的相对宽颈动脉瘤。 METHODS:AneurysmstreatedwiththePulseRiderdeviceamongsitesenrollingintheANSWERtrialwereprospectivelystudiedandtheresultsaresummarized.AneurysmsarisingateitherthecarotidterminusorbasilarapexthatwererelativelybroadneckedwereconsideredcandidatesforinclusionintotheANSWERstudy. 结果：全组34例，其中女性29例，男性5例；平均年龄60.9岁；动脉瘤位于基底动脉尖27例，位于颈内动脉末端7例；动脉瘤体长径2.4-15.9mm，瘤颈平均直径5.2mm（2.3-11.6mm）。全组患者均使用PulseRider支架，术后动脉瘤Raymond-Roy闭塞分级I或II级者达82.4%，术后6个月随访增加到87.9%；94%的患者术后6个月改良Rankin评分≤2分。 RESULTS:Thirty-fourpatientswereenrolled(29femaleand5male)withameanageof60.9years(27basilarapexand7carotidterminus).Meananeurysmheightrangedfrom2.4to15.9mmwithameannecksizeof5.2mm(range2.3-11.6mm).Inallpatients,thedevicewasdeliveredanddeployed.ImmediateRaymondIorIIocclusionwasachievedin82.4%andprogressedto87.9%at6-monthfollow-up.AmodifiedRankinScoreof2orlesswasseenin94%ofpatientsat6months. 结论：ANSWER试验结果表明，使用PulseRider支架治疗基底动脉尖或颈内动脉末端的分叉部动脉瘤是安全的，且有可能获益，可以作为神经血管内治疗装备的有益补充。 CONCLUSION:TheresultsfromtheANSWERtrialdemonstratethatthePulseRiderdeviceissafeandoffersprobablebenefitasforthetreatmentofbifurcationaneurysmsarisingatthebasilarapexorcarotidterminus.Assuch,itrepresentsausefuladditiontothearmamentariumoftheneuroendovascularspecialist. 关键词：动脉瘤，栓塞治疗，装备 KEYWORDS:Aneurysm,Embolization,Device 原文出处：SpiottaAM,DerdeynCP,TateshimaS,etal.ResultsoftheANSWERTrialUsingthePulseRiderfortheTreatmentofBroad-Necked,BifurcationAneurysms.Neurosurgery.;81(1):56–65. 赞赏 长按北京中科中医院北京哪家医院白癜风治得好
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